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Dopamine is responsible for keeping our brains firing on all cylinders. When we lose dopamine, it causes abnormal patterns which can make it difficult to move. Studies have found that people with Parkinson's disease have lost 60-80% of the dopamine in their substantia nigra- which is the area of the brain responsible for producing dopamine. We also know that PD patients have a loss of the nerve endings that produce norepinephrine.